Epidemiology, treatment patterns and outcomes in patients with coronary or lower extremity artery disease in France
G. Montalescot
Summary
Background. - There is a dearth of updated epidemiological data on the prevalence and annual incidence of coronary artery disease (CAD) and lower extremity artery disease (LEAD) in Western countries.
Aims. - To describe the incidence and prevalence of CAD and LEAD, associated medication patterns and long-term outcomes in France.
Methods. - This was a retrospective cohort study using French claims data from a representative sample of the French general population. Any hospitalization or long-term disease status for CAD or LEAD between January 2010 and December 2016 was collected to identify incident cases.
Results. - Of the 763,338patients screened in the study period, 8559 incident cases of CAD and 4399 of LEAD were identified, with an overall mean follow-up of 2.9±2.0years. The incidence of CAD, LEAD and CAD or LEAD remained stable over the years, and in 2016 were at 33.5 per 10,000person-years, 15.1per 10,000person-years and 42.5 per 10,000person-years, respectively. The prevalence of CAD increased from 3.1% in 2010 to 4.2% in 2016, and LEAD from 1.6% to 2.4%. Most patients received guideline-recommended medication with antithrombotic drugs and lipid-lowering drugs following the index event. However, most of the medications initiated were subsequently discontinued during follow-up. Incident CAD or LEAD was associated with considerable morbidity–particularly an incidence of all-cause hospitalization of 7976.9 per 10,000person-years–and all-cause mortality, with an incidence of 542.8 per 10,000person-years.
Conclusion. - In recent years, the prevalence of CAD or LEAD has increased progressively, resulting in considerable morbidity and mortality.
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